Revised microcalcification hypothesis for fibrous cap rupture in human coronary arteries
نویسندگان
چکیده
منابع مشابه
Revised microcalcification hypothesis for fibrous cap rupture in human coronary arteries.
Using 2.1-µm high-resolution microcomputed tomography, we have examined the spatial distribution, clustering, and shape of nearly 35,000 microcalcifications (µCalcs) ≥ 5 µm in the fibrous caps of 22 nonruptured human atherosclerotic plaques. The vast majority of these µCalcs were <15 µm and invisible at the previously used 6.7-µm resolution. A greatly simplified 3D finite element analysis has m...
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AIMS The widely accepted threshold of <65 μm for coronary plaque fibrous cap thickness was derived from postmortem studies of ruptured plaques and may not be appropriate for in vivo rupture-prone plaques. We investigated the relationship between fibrous cap thickness and plaque rupture using optical coherence tomography (OCT). METHODS AND RESULTS We studied 266 lesions (103 from patients with...
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Fibrous Cap Thickness and Rupture in Carotid Atheromata: Still Hunting in the Dark? To the Editor: Redgrave et al1 are to be congratulated for their superb and cumbersome work. We had been waiting for a large welldesigned histopathologic study focusing exclusively on the critical cap thickness of carotid atheromata, and we are grateful for this important contribution. Hitherto, data extrapolati...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 2013
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.1308814110